The 41-year-old rap producer advised Twitter followers to "unprogram" their minds and stop relying on social media to tell them how to think or what to do.
Kanye, who has been heavily criticized for supporting President Trump and wearing a red "Make America Great Again" ball cap, said social media poisons and enslaves the mind.
The rapper said social media is "incentivizing" users to use the platform "based off you getting enough likes, and that's the poison that's happening with social media."
Kanye, who is currently in Africa, discussed the pressure that social media places on people to think like a group rather than to think individually.
Jack Dorsey, co-founder and CEO of Twitter, told Kanye that Twitter engineers would work over the next four months to reprogram Twitter to allow users to remove their 'Likes' and follow counts, "because that works against your self worth."
Kanye also discussed his ongoing negotiation with his record label to buy back the rights to his masters. He compared himself to the late musician Prince who publicized his battle with Warner Bros. to buy back his masters.
"I need my publishing. I got the money," said Kanye. "I'm not gonna say the 'S' word. I'm not Prince; I don't need to write it on my face.
Watch the entire video below.