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Mo’Nique reignited her bitter feud with Tyler Perry and Oprah Winfrey in a profanity-laced tirade during “The Dark Matter Tour” stop in Nashville, Tennessee.

Mo’Nique led the audience in an expletive-filled chant: “F*** them coon mutha******s! I said it, ni**a, say it with me! F*** you Oprah Winfrey, f*** you Tyler Perry! You coon mutha******s”

Mo’ declared her love for “that Black raggedy b*tch,” referring to Oprah as “simple-minded”. “I love Oprah Winfrey’s Black a**, and we just need to bring her back to black.”

Then Mo’Nique singled out an audience member named “Melvin”. She asked him if he was willing to help bring Oprah “back to black” by sleeping with the billionaire mogul.

Mo’Nique waved off Melvin’s partner, saying, “Oh, b*tch be quiet. You gonna get some money out of it.”

Mo’Nique’s rant made some audience members uncomfortable. They were seen getting up and walking out of the venue during her tirade.

John Shearer/Getty Images

The standup comedienne also commented on Oprah’s longtime relationship with fellow journalist Gayle King. Mo’Nique noted she hasn’t seen Oprah’s longtime partner, Stedman Graham, in decades.

“Who is loving Oprah and Gayle King? Each other. But we can’t say that s*** out loud,” she said.

Watch Mo’Nique’s rant below.

CAUTION: Video contains profanity and graphic language which may not be suitable for most viewers or the workplace.