Sean Penn and Arnold Schwarzenegger blasted Americans who refuse to get vaccinated or wear face masks.
Penn defended his demand that all cast and crew on his UCP series set get vaccinated.
Fox News reports the 60-year-old actor announced he would not return to the set of Watergate drama "Gaslit" until everyone on the set got the experimental shots.
Madonna's ex then demanded everyone in the United States do the same.
Penn compared vaccines to driver's licenses, saying people who don't take the mRNA injections shouldn't be allowed to drive.
He also called on all corporations to force vaccinations on their employees.
"This is one of those things that should be mandatory that we all get with the exception," he told Yahoo News.
"The very few exceptions are those people who, for whatever reason, a medical condition might offset it.
"But I do think that business, all businesses, need to take the lead and to be not so timid in dealing with their collective bargaining agreement partners."
In related news, former California governor Arnold Schwarzenegger raised eyebrows when he said Americans who refuse to wear masks should lose their freedom: "Screw your freedom!"
"There is a virus here, it kills people," he said.
"The only way we prevent it is get vaccinated, get masks, do social distancing, washing your hands all the time, and not just to think about, 'Well my freedom is being kind of disturbed here.' No, screw your freedom!"
"Because with freedom comes obligations and responsibilities, you cannot just say, 'I have the right to do X, Y and Z,' when you affect other people, that is when it gets serious. It's no different from a traffic light, you put a traffic light at an intersection so someone doesn't kill someone else."
Watch Arnold's rant below.