Bowie was best known for his #1 hits "Let's Dance" and "Fame". He released his last studio album, Blackstar, on his 69th birthday.
Bowie was born David Jones in London, England on Jan. 8, 1947. He is survived by his wife of 24 years, former supermodel Iman, and their daughter Alexandria Zahra Jones, 15. Bowie also has a son, Duncan Jones, 44, from a previous relationship.
Iman gave a hint into Bowie's impending death in a series of emotional posts on social media on Saturday.
She shared a message on Instagram.com that read: "The struggle is real but so is God." She also posted a message that read: Sometimes you will never know the true value of a moment until it becomes a memory."
In a previous interview, Bowie said he started "naming the children the first night we met."
But it wasn't love at first sight for Iman. "I was not ready for a relationship," Iman told the Guardian newspaper in 2013.
"Definitely I didn't want to get into a relationship with somebody like him. But as I always said: I fell in love with David Jones. I did not fall in love with David Bowie."
Iman added, "Bowie is just a persona. He's a singer, an entertainer. David Jones is a man I met."
Bowie's son, Duncan Jones, also shared his grief on social media.
Jones's wife, Rodene Ronquillo, is a breast cancer survivor. Jones said he rushed Ronquillo to the courthouse and married her a few hours after she was diagnosed with breast cancer on Nov. 7, 2013.
He later shaved his head bald in tribute to her after she lost her hair following chemotherapy treatments.
Bowie was diagnosed with cancer 18 months after Ronquillo, 35, learned she had cancer.
Jones tweeted, "Women are getting breast cancer younger & younger. Women? Check yourselves! ..& men?"