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Heather McDonald shocked her fans when she collapsed, fracturing her skull, during a comedy routine three weeks after getting her third mRNA vaccine.

McDonald was performing in front of a sold-out audience during a comedy show in Tempe, Arizona when she suddenly fell flat on her back.

The crowd laughed – apparently believing her sudden loss of consciousness was part of the show.

Ironically, McDonald had just joked that she was “double-vaxxed, boostered,” before claiming Jesus loves her the most. She said she also received the flu and shingles shots.

The 51-year-old comedian was briefly hospitalized with a concussion after her medical scare.

During a recent interview with Dr. Drew, McDonald confirmed she was triple vaccinated — having received her third mRNA dose just three weeks before she collapsed without warning.

She asked Dr. Drew about the adverse effects and when they happen, to which he replied, “two to three weeks.”

McDonald then said she is not getting the 4th mRNA booster shot.

McDonald is best known as a writer for Chelsea Lately and her popular podcast “Juicy Scoop with Heather McDonald.”

Handler, 46, also suffered a health scare during a stand-up routine and was hospitalized days before McDonald’s fainting episode. Handler, who is fully vaccinated, has canceled her shows for the rest of the month.